Do I have to keep the lesion covered?

As mentioned above, Perrin's Blend is a sticky honey based ointment and burgundy in color due to the grape seed extract which means it will stain clothes.  Even though we have seen positive results with sporadic application, the best results come when the lesion is in constant contact the Perrin's Blend.  That also means leaving the bandage on during a bath, then not washing it off before reapplying.  Most of the time the lesion needs to be covered to prevent the Perrin's Blend from being rubbed off.  If the place is on your face (where there is less of a chance of the ointment being rubbed off) and you do not mind the appearance of the ointment, then there may not be as much of a reason to keep the area covered, and you can (if needed) keep reapplying during the day.